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Terrence L. Cascino, MD

Arch Neurol. 1991;48(2):227.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Over the past 30 years, tremendous effort has been put into discovering effective therapy for primary brain tumor. For the most part, these efforts have concentrated on high-grade gliomas. It has clearly been shown that these tumors are radiosensitive in some cases. There remains great pessimism, though, regarding these tumors, with many patients having little response to chemotherapy at the time of recurrence. This has spurred great interest in novel drugs and new methods of drug delivery to try to increase the effectiveness of chemotherapy.

Cairncross and Macdonald have made the observation that anaplastic oligodendrogliomas may be a subgroup of glioma, which, in fact, is highly chemosensitive. This is an extremely important observation for a number of reasons. If their observations are correct, neuro-oncologists can point to an example of a high-grade glioma whose course can be radically changed by the administration of chemotherapy. Hopefully, this will promote further interest . . . [Full Text PDF of this Article]

Author Affiliations
From the Department of Neurology, Mayo Clinic, 200 First Ave SW, Rochester, Minn.

Footnotes
Accepted for publication September 20, 1990.

Reprint requests to Department of Neurology, Mayo Clinic, 200 First Ave SW, Rochester, MN 55905 (Dr Cascino).

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