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Frank Morrell, MD

Arch Neurol. 1991;48(12):1221-1224.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Approximately one third of patients with focal epilepsy exhibit bilateral, mainly homotopic, apparently independent, epileptiform electroencephalographic (EEG) abnormalities in scalp-recorded tracings under normal physiologic recording conditions.^1-4 Although this finding is well established, its significance with respect to pathophysiology is unclear. For example, does it mean that both hemispheres contain an epileptogenic lesion that is at least potentially clinically significant? Do these bilateral discharges imply that there are multiple primary foci and, if so, why are they so often symmetrical? Or, is it possible that one epileptogenic lesion may give rise to another? Equally obscure is the meaning of such bilateral epileptiform discharge with respect to the outcome of surgical treatment. Does the presence of an active spike focus contralateral to an intended excision afford a warning that the operative intervention is unlikely to result in cure? Is it rather a warning that operative intervention is needed more quickly? Or, . . . [Full Text PDF of this Article]

Author Affiliations
Chicago, Ill

From the Department of Neurological Sciences, Rush Medical College, Chicago, Ill.

Footnotes
Accepted for publication August 19, 1991.

Reprint requests to Department of Neurological Sciences, Rush Medical College, 1653 W. Congress Pkwy, Chicago, IL 60612 (Dr Morrell).

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