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Barry Zeeberg
The George Washington University Medical Center Walter G. Ross Hall 2300 Eye St NW Washington, DC 20037

Arch Neurol. 1991;48(11):1117-1118.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.

—A recent article by Weinberger et al¹ describes the distribution of cerebral muscarinic acetylcholine receptors (mAChR) in vivo in patients with Alzheimer's disease (AD) using single photon emission computed tomographic (SPECT) imaging of the distribution of radioiodinated 3-quinuclidinyl-4-iodobenzilate ((R,R)-[¹²³I]IQNB), a specific radioligand for the mAChR.² The primary observation is that there is "... a significant reduction bilaterally in the posterior temporal cortex of the patients with Alzheimer's disease compared with controls..." The authors conclude, "... It is likely that the images reflect the distribution of the relative density of a subpopulation of muscarinic receptors. The majority of the patients with primary degenerative dementia had qualitatively abnormal IQNB SPECT scans, perhaps because of focal areas of reduced receptor density..." However, although it is possible that the (R,R)-[¹²³I]IQNB localization deficits reflect a mAChR deficit, as we show below, the argument presented to distinguish this possibility . . . [Full Text PDF of this Article]

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