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A Commentary on Correlates Between Cerebrospinal Fluid -Globulins and Magnetic Resonance Imaging in Multiple Sclerosis-Reply

Felix A. J. Müller, MD
Neurologische Abteilung Kantonsspital 8596 Münsterlingen, Switzerland

Paul E. Hänny, MD
Neurologische Klinik

Walter Fierz, MD
Klinische Immunologie Universitätsspital 8091 Zürich, Switzerland

Arch Neurol. 1990;47(8):842-843.

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In Reply.

—In agreement with Baumhefner et al, we find it important that both studies, theirs and ours, came to the same conclusion: they have shown positive correlation between cerebrospinal fluid IgG concentration with the extent of cerebral lesions as measured by magnetic resonance imaging; also both of these correlate well with visual-evoked potential latencies. The fact that these results were obtained through distinctly differing methods can only add to their significance, also decreasing vulnerability caused by artifacts.

Referring to the first point, please note that our global magnetic resonance imaging score incorporates both regions of hyperintensic changes, the intraparenchymatous focus, and the periventricular bright zones. If we independently calculate correlations between these two cerebral regions and the changes of the immunoglobulin content in cerebrospinal fluid, the value for the periventricular changes (r =.43) is slightly better than for the intracerebral plaque (r =.40), and both are highly significant. We . . . [Full Text PDF of this Article]

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