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  Vol. 47 No. 4, April 1990 TABLE OF CONTENTS
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Tubular Aggregates in Skeletal Muscle Associated With Neoplastic Disease

Jack E. Riggs, MD; Sydney S. Schochet, Jr, MD; Ludwig Gutmann, MD
Department of Neurology West Virginia University Health Sciences Center Morgantown, WV 26506

Arch Neurol. 1990;47(4):382-383.

Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.

—Tubular aggregates in skeletal muscle have been described in an increasing variety of disorders, including periodic paralysis; muscular dystrophies; inflammatory myopathies; chronic alcoholism; familial neuromuscular disease characterized by myalgia; and a variety of drug exposures, including anticonvulsants.1-7 We report the observation of tubular aggregates in skeletal muscle from a patient with neoplastic disease and suggest that a pathogenetic relationship may exist between the development of tubular aggregates and the disturbance in calcium metabolism and regulation that frequently occurs in neoplastic disease.

Report of a Case.

—A 73-year-old man with no prior history of myalgias, muscle cramps, or muscle weakness presented with a 3-month history of orthostatic hypotension with occasional syncope, night sweats, and a 7-kg weight loss. His blood pressure was 120/60 mm Hg supine, with a pulse rate of 90 beats per minute. On standing, his blood pressure dropped to 70/42 mm Hg, with a . . . [Full Text PDF of this Article]



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