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Richard A. Rudick, MD
Department of Neurology Mellen Center for Multiple Sclerosis Treatment and Research

Barbara P. Barna, PhD
Department of Immunopathology Cleveland Clinic Foundation Cleveland, OH 44106

Arch Neurol. 1990;47(3):254-255.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.

—Elevated levels of serum interleukin 2 (Il-2) and soluble interleukin 2 receptor (sIl-2r) have been related to active sarcoidosis.¹ It has been suggested that this may reflect disease activity, since Il-2 is secreted by activated T lymphocytes and sIl-2r is shed by activated T lymphocytes during the course of a cell-mediated immune response.² Boutin and associates³ reported that serum levels of sIl-2r were markedly increased in patients with acute encephalitis, suggesting that the intrathecal immune response was reflected by elevated systemic levels of sIl-2r. Elevated systemic levels of Il-2 and sIl-2r have been reported in patients with multiple sclerosis,^4-6 stimulating questions about whether these parameters can be used to measure disease activity, to estimate prognosis, or to explain certain clinical manifestations of the disease.

We measured Il-2 and sIl-2r in eight patients with multiple sclerosis who each experienced persisting and debilitating fatigue. All . . . [Full Text PDF of this Article]

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