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A Neurologist's Concern

Saran Jonas, MD

Arch Neurol. 1990;47(12):1352-1353.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Should a neurologist recommend that an asymptomatic and healthy man take aspirin for prophylactic purposes on a long-term basis? This communication reviews the issues engendered by this question.

The results of two large studies have been published in the past 2 years in which healthy male physicians were randomized for long-term prophylactic aspirin treatment or for assignment to a control cohort. The subjects were followed up for an average of 5 to 6 years. The Physicians' Health Study (PHS),¹ done in the United States (aspirin, 325 mg every other day), showed a 44% reduction in the risk of myocardial infarction (MI); the P value was less than.00001. The British study (BS)² showed no such benefit (aspirin, 300 to 500 mg daily). Rates for deaths from all causes were somewhat lower in the aspirin cohorts in both studies, but the reductions were not statistically significant. In both studies, the . . . [Full Text PDF of this Article]

Author Affiliations
From the Department of Clinical Neurology, New York University School of Medicine, New York.

Footnotes
Accepted for publication June 7, 1990.

Reprint requests to 530 First Ave, New York, NY 10016 (Dr Jonas).

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