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Richard B. Rosse, MD
Psychiatry Service Washington Veterans Administration Medical Center 50 Irving St NW Washington, DC 20422

Arch Neurol. 1989;46(8):841-842.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.

—I read the article "Fatigue in Multiple Sclerosis" by Krupp et al¹ in the April 1988 issue of the ARCHIVES with interest. In that article, the fatigue frequently experienced by patients with multiple sclerosis (MS) is characterized and proved to be more frequent and severe than the fatigue experienced by normal healthy adults. Interestingly, the fatigue of patients with MS seemed independent of severity of the patients' neurologic deficits, and the severity of the fatigue did not correlate well with depression. I would like to point out some recent developments that might have some role in an improved understanding of MS fatigue. Trotter et al² have reported finding elevated serum interleukin 2 (IL-2) levels in patients with progressive MS, and Greenberg et al³ have reported finding elevated serum levels of the released form of the IL-2 receptor in patients with MS. Denicoff et al . . . [Full Text PDF of this Article]

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