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Steven Demeter, MD
Departments of Neurology and Psychiatry University of Rochester Medical Center Box 605 Rochester, NY 14642

Douglas L. Rosene, PhD
Department of Anatomy Boston University School of Medicine Boston, MA 02118

Gary W. Van Hoesen, PhD
Department of Anatomy University of Iowa College of Medicine Iowa City, IA 52242

Arch Neurol. 1989;46(7):723-724.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.

—The observations of Moossy et al¹ in a recent issue of the ARCHIVES on the distribution of the neuropathologic lesions of Alzheimer's disease are of interest, since there appear to be parallels between the symmetry (or lack thereof) of neurofibrillary tangles and the presence (or absence) of interhemispheric neuronal connections. These investigators reported that neuritic plaques are distributed symmetrically in the superior frontal and superior temporal gyri, prosubiculum, and entorhinal cortex, whereas neurofibrillary tangles are distributed symmetrically in neocortical areas but asymmetrically in the prosubiculum and entorhinal cortex.

To the extent that these observations are accurate, it is noteworthy that macaques have prominent interhemispheric connections in neocortical association areas² (S.D., D.L.R., G.W., V.H., unpublished observations, 1989), while such connections are lacking in all but the most rostral part of the hippocampal formation.^3,4 Moreover, the entire extent of the prosubiculum lacks interhemispheric connections. Whereas neocortical . . . [Full Text PDF of this Article]

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