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Fragile X Syndrome: A Genetic Etiology for Developmental Gerstmann's Syndrome
JiM Grigsby, PhD
Rocky Mountain Multiple Sclerosis Center PO Box 2901, Dept 7500 Englewood, CO 80110
Randi Hagerman, MD
Child Development Unit Children's Hospital 1056 E 19th Ave Denver, CO 80218
Arch Neurol. 1989;46(12):1269-1270.
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To the Editor.
—We read with interest the recent article by PeBenito et al1 of several cases of developmental Grestmann's syndrome. We were concerned that mention was not made of fragile X syndrome as a possible cause. The validity of Gerstmann's syndrome,2,3 which is comprised of dysgraphia, dyscalculia, finger agnosia, and right-left disorientation, has been the subject of considerable debate.4-10 The same has been true of the developmental Gerstmann syndrome (DGS), which also includes deficits in constructional praxis.11,12
PeBenito et al reported on five children who had all five signs of the developmental Gerstmann disorder, as well as various combinations of motor and attentional problems. Four of the five had at least average reading ability. In their discussion, the authors state that "the etiology of DGS is unknown. Whereas some specific learning disorders (eg, dyslexia) have a familial tendency, this is not observed in DGS" (p
. . . [Full Text PDF of this Article]
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