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William Rosenfeld, MD
Department of Neurology St Louis University Medical Center Doctor's Office Building 3660 Vista Ave St Louis, MO 63110

Arch Neurol. 1988;45(6):603.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In Reply.

—The comments by Drs

Lanska and Osorio are appreciated and further confirm the work of Sackellares and others in regard to stupor as an "unusual complication following the addition of valproic acid to other antiepileptic drugs."¹

However, their case does not directly apply to our recent article,² since we were administering a single loading dose of valproic acid in most cases (occasionally, a second dose) to prevent a flurry of generalized tonic-clonic seizures. In our original article, 35 patients were administered a loading dose and, since that time, at least an equal number of administrations has been performed, and we have had no similar complication. In the case of Drs Lanska and Osorio, the patient appears to have developed her stuporous condition approximately 36 hours after introduction of valproic acid when she was almost at steady state (chronic therapy), having received approximately five to six half-lifes of . . . [Full Text PDF of this Article]

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