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NeurofibromatosisConference Statement
National Institutes of Health Consensus Development Conference
Arch Neurol. 1988;45(5):575-578.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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The neurofibromatoses are genetic disorders that primarily affect cell growth of neural tissues. These disorders can cause tumors to grow on the nerves at any location and at any time. Some manifestations are progressive, and may result in significant morbidity or mortality. Two distinctive forms are recognized, but variant forms may exist. A variety of names have been used to describe all forms; subsequent information has made these names technically inaccurate or incomplete. To avoid these historical legacies and to conform to current nosology in other diseases, the Consensus Panel adopted a numbered classification.
The most common type, neurofibromatosis 1 or NF-1 (previously known as von Recklinghausen's neurofibromatosis or peripheral neurofibromatosis), is an autosomal dominant disorder affecting about 1 in 4000 individuals. Multiple hyperpigmented areas (cafe au lait macules) and neurofibromas are characteristic.
Neurofibromatosis 2 or NF-2 (previously known as bilateral acoustic neurofibromatosis or central neurofibromatosis) is an autosomal dominant
. . . [Full Text PDF of this Article]
Author Affiliations
From the Office of Medical Applications of Research, National Institutes of Health, Bethesda, Md.
Footnotes
Accepted for publication Aug 19, 1987.
Presented at the National Institutes of Health Consensus Development Conference, Bethesda, Md, July 13 through 15, 1987.
A complete listing of the participants in this study appears at the end of this article.
Reprints not available.
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