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David M. Bear, MD; Mark Agostini; Jose A. Saporta, JR
Departments of Psychiatry and Neurology Vanderbilt University School of Medicine Nashville, TN 37322

Arch Neurol. 1988;45(3):248.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.

—An extensive set of observations and theory relating level of intrauterine testosterone to anomalous cerebral dominance, sexual behavior, and immune function was reported in the ARCHIVES.¹ These concepts led us to examine cerebral asymmetries among homosexual men with confirmed acquired immunodeficiency syndrome (AIDS).

Using standardized quantitative methods² we measured differences in width and length at the frontal and occipital poles on computed tomographic scans of 16 patients with AIDS, comparing the results with our published values for 31 normal men.² No scan showing a mass lesion or midline shift was included in the analysis.

In the AIDS sample, we found a significant reversal of frontal width asymmetry. Compared with the average right frontal predominance reported in multiple studies² (x = 3.47% of total brain width in our control group), AIDS patients showed a mean left frontal predominance (x = 0.34%;^t = 2.85;^P<.01). Reversal . . . [Full Text PDF of this Article]

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