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Emanuele Bosi, MD; Aurelio Vicari, MD; Giancarlo Comi, MD; Mauro Comola, MD; Nicola Canal, MD; Guido Pozza, MD
Departments of Medicine and Neurology Istituto Scientifico Ospedale San Raffaele 20132 Milan, Italy

Gian Franco Bottazzo, MD, MRCP, MRCPath
Department of Immunology Middlesex Hospital Medical School 40-50 Tottenham St London W1P 9PG, England

Arch Neurol. 1988;45(3):246-247.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.

—We report a case of association between stiff-man syndrome, type I diabetes, and autoimmune polyendocrine/organ-specific serologic findings.

Report of a Case.

—A 49-year-old obese woman was admitted in January 1983 because of stiffness of the lower back, thighs, and legs, and intermittent painful muscle spasms of the entire body: spasmodic muscle contractions occurred spontaneously and lasted for several minutes. Clinical and electromyographic studies were diagnostic for stiff-man syndrome, a rare neurologic disorder of unknown etiology. This condition is characterized by fluctuating rigidity of axial and limb muscles due to continuous muscle fiber spasm, without signs of cerebral and spinal cord impairment, and with continuous electromyographic activity.¹ At that time fasting serum glucose concentration was normal. She was treated with diazepam, with remarkable improvement. In August 1985, she was admitted to the intensive care unit because of ketoacidotic coma. Her personal and family history were unremarkable . . . [Full Text PDF of this Article]

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