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Christopher M. Filley, MD; Robert K. Heaton, PhD
University of Colorado Health Sciences Center Denver, CO 80262

Arch Neurol. 1987;44(8):797-798.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In Reply.

—Our study was undertaken primarily to test the hypothesis of Seltzer and Sherwin¹ regarding the greater degree of language impairment in younger patients with Alzheimer's disease (AD). The observation that significant linguistic disturbances can occur in this group is not new^2,3 and, indeed, Alzheimer's first case was a woman in her 50s who had a language deficit in addition to memory loss and personality change.⁴ Our results provide qualified support for Seltzer and Sherwin's claim and further suggest that older patients with AD may suffer more from visuoconstructional deficits. The tests on which we base these preliminary conclusions—the Aphasia Screening Test (AST) and the Spatial Relations measure—have been shown in previous work to be sensitive to left and right hemisphere dysfunction, respectively.⁵

The three studies cited by Koss and Friedland are of interest, but we are uncertain of their significance. Loring and Largen⁶ reported greater . . . [Full Text PDF of this Article]

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