This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Walter G. Bradley, DM, FRCP
Department of Neurology University of Vermont Burlington, VT 05405

Frank Krasin, PhD
Department of Radiobiology Tufts-New England Medical Center Boston, MA 02111

Arch Neurol. 1987;44(6):580-581.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In Reply.

—We are surprised that Dr Robbins has waited almost four years after the publication in 1982 of our article entitled "A New Hypothesis of the Etiology of Amyotrophic Lateral Sclerosis: The DNA Hypothesis"¹ to submit the above letter. We dispute Dr Robbins' claim that he and his colleagues were the first to propose the DNA-damage hypothesis of human neurologic disease, and we will briefly review the history of this hypothesis as we see it.

One of us (W.G.B.) has been undertaking work on the etiology of amyotrophic lateral sclerosis (ALS) for a number of years.^2-6 In our 1982 article¹ we brought together work from a number of different fields to produce a cohesive hypothesis that might explain the etiology of ALS. This hypothesis derived from the seminal 1974 article of Mann and Yates,⁷ in which they reported RNA, nuclear, and nucleolar changes in ALS motor neurons . . . [Full Text PDF of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?