This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Roger Kurlan, MD

Arch Neurol. 1987;44(11):1119-1121.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In the October issue of the ARCHIVES, Pincus and Barry¹ and Juncos and colleagues² provided seemingly contradictory reports concerning the efficacy of a low-protein dietary approach for the treatment of motor fluctuations in Parkinson's disease.

Fluctuations in motor performance remain a major problem in the long-term care of levodopa-treated patients with Parkinson's disease. Although the pathogenesis of such fluctuations remains incompletely understood, several recent findings are helping to clarify the underlying mechanisms, are contributing to improved therapeutic approaches, and can serve to help place dietary therapy in proper perspective.

Both pharmacokinetic factors affecting the delivery of levodopa to the brain and pharmacodynamic factors influencing dopamine receptor function are postulated causes for the fluctuations. Guttman and colleagues³ measured densities of the dopamine receptor subtype (D2) linked to the motor disturbances of parkinsonism in postmortem samples of the striatum from 36 parkinsonian patients and found that D2 receptor . . . [Full Text PDF of this Article]

Author Affiliations
Rochester, NY

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?