This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Do They Have a Role? No

Bryce Weir, MDCM, MSc, FRCS(C)

Arch Neurol. 1987;44(1):116-118.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In the mid 1960s, Mullan and Dawley,¹ in the course of experimental work, noted that electrically induced thrombi in the femoral artery of dogs, which were normally of short duration, could be made to last longer when the antifibrinolytic agent -aminocaproic acid was administered. This observation induced them to use the same agent in an attempt to prevent recurrent hemorrhage in patients who had recently suffered subarachnoid hemorrhage from ruptured aneurysms. In 1965, Norlén and Thulin² had found the same agent to be of value during the surgery on two cases of arteriovenous malformations. This also had led them to employ antifibrinolytic agents in the management of ruptured saccular aneurysms, virtually simultaneously with Mullan and Dawley. The reasoning in both investigations was similar. If the dissolution of the hemostatic clot at the site of rupture could be delayed, the definitive operative procedure for the repair of the . . . [Full Text PDF of this Article]

Author Affiliations
From the Division of Neurosurgery, Department of Surgery, University of Alberta, Edmonton, Alberta, Canada.

Footnotes
Accepted for publication Aug 3, 1986.

Reprint requests to Division of Neurosurgery, Department of Surgery, 202-44 W. C. Mackenzie Health Sciences Center of the University of Alberta, Edmonton, Alberta, Canada T6G 2G3 (Dr Weir).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?