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Alain Destee, MD; Didier Leys, MD; Brigitte Delisse, MD; Pierre Warot, MD
Department of Neurology Lille University Hospital 2, Avenue Oscar Lambret F-59037 Lille Cedex, France

Arch Neurol. 1987;44(1):11.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.

—Orthostatic hypotension (OH) during diabetic autonomic neuropathy is frequent, treated with difficulty,¹ and associated with a high death rate.² Recently, indomethacin therapy has been proposed, but it is not devoid of side effects and exposes patients who already have a high risk of vascular diseases to clinostatic hypertension and coronary vasocon-striction.³ Metoclopramide dichlorhydrate therapy has been used with success in a case of severe OH after an extensive sympathectomy.⁴ Therapy with metoclopramide has frequent side effects, however.⁵ Domperidone, which antagonizes dopaminergic transmission, does not cross the blood-brain barrier⁶ and, theoretically, would be more easily tolerated. Therefore, we decided to treat a patient with diabetic OH by domperidone therapy.

Report of a Case.

—In November 1982, ketoacidosis diabetes was discovered in a 70-year-old woman with bilateral cataract, arthritis in her lower limbs, and ulceration of the soles of her feet.

Blood . . . [Full Text PDF of this Article]

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