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Robert B. Daroff, MD

Arch Neurol. 1986;43(8):843-844.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The technique for intravenous administration of Tensilon (edrophonium chloride) varies. In 1952, Osserman and Genkins¹ introduced the test and recommended a 2-mg initial dose followed, if no reaction (usually cholinergic) occurred in 45 s, by the rapid administration of an additional 8 mg. Others have modified the test by waiting five minutes after the initial dose,² by injecting Tensilon in small increments after the initial dose,^2-6 or by slowly infusing the remaining 8 mg.⁵ Although I have recently been converted by Norman Schatz, MD, to the small-increment method, the significant controversy this essay should address is not drug administration but rather the test end point. What constitutes a "positive" Tensilon response in the physician's office where (without benefit of oculographic equipment^7-10) the first Tensilon test is performed in a suspected myasthenic? Such a determination is obviously important since a positive test is virtually diagnostic of . . . [Full Text PDF of this Article]

Author Affiliations
From the Departments of Neurology, Case Western Reserve University School of Medicine, Cleveland, and University Hospitals of Cleveland, and the Neurology Service, Cleveland Veterans Administration Medical Center.

Footnotes
Accepted for publication March 10, 1986.

Reprint requests to Department of Neurology, University Hospitals of Cleveland, Cleveland, OH 44106 (Dr Daroff).

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