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Vanda A. Lennon, MD, PhD
Departments of Immunology and Neurology Mayo Medical School Rochester, MN 55905

Arch Neurol. 1986;43(10):981-982.

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—Numerous factors influence the induction of experimental autoimmune encephalomyelitis (EAE) or neuritis (EAN) by active immunization. The most important of these are the immunocompetence of the host (including age, genetic, hormonal, infectious, and other environmental factors), the dose and potency of the specific antigen (eg, myelin basic protein, peripheral nerve P2 protein, ganglioside, or galactocere-broside), and the potency of the adjuvant used to break immunologic tolerance to "self" antigens. The more potent the antigenic challenge, the less critical is the composition of the adjuvant.

The importance of the composition of adjuvants in determining whether or not an autoimmune neurologic syndrome will occur after immunization with neural antigens is well documented. A classic article on this subject was written by Shaw et al (including Alvord)¹ in 1962. A conclusion of that report (dealing with EAE) was that in three species "the data are quite consistent in requiring central nervous tissue . . . [Full Text PDF of this Article]

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