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Forbes H. Norris, MD
ALS & Neuromuscular Research Center Pacific-Presbyterian Medical Center Box 7999 San Francisco, CA 94115

Paul I. Terasaki, PhD
Department of Surgery UCLA School of Medicine Los Angeles, CA 90024

Brian Henderson, MD
Department of Preventative Medicine University of Southern California School of Medicine Los Angeles, CA 90033

Arch Neurol. 1986;43(1):7.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

Several reports, most recently by Bartfeld et al,¹ indicate possible HLA system involvement in amyotrophic lateral sclerosis (ALS). For example, Bartfeld and co-workers¹ found a trend toward increased frequency of HLA-Bw35, in agreement with Kott et al.² What has not been emphasized is that statistical trends are not important when other studies find different trends. For example, Antel et al³ found increases of HLA-A3 in rapidly progressive ALS and HLA-Bw12 in ALS with slower courses. Kott et al² also found a significant increase in HLA-A3; they stated that their HLA-Bw35 increase was not significant. Jokelainen et al⁴ found an increased incidence of HLA-Bw40 in ALS cases with slower courses. Behan and colleagues⁵ report . . . [Full Text PDF of this Article]

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