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by A. E. Harding, 226 pp, $56, New York, Churchill Livingstone Inc, 1984.

William J. Kingston, MD, Reviewer
Rochester, NY

Arch Neurol. 1986;43(1):11.

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Dr Harding has provided an excellent clinically oriented approach to the diagnosis and management of hereditary ataxias and spastic paraplegias. Chapter 1 includes a historical perspective and delineates problems of classification of these disorders. The classification system presented is based on an extensive review of the literature and personal experience with over 20 families. Congenital cerebellar ataxias of unknown cause are discussed in chapter 2. Chapter 3 focuses on ataxic disorders associated with known metabolic defects, while chapter 4 reviews those ataxias associated with defective DNA repair. Early-onset ataxic disorders (onset before age 20 years) are covered in chapters 5 through 9, with chapter 5 devoted entirely to Friedreich's ataxia. Chapters 10 and 11 present the autosomal dominant and idiopathic varieties of late-onset cerebellar ataxias. The hereditary spastic paraplegias. The hereditary spastic paraplegias are reviewed in chapters 12 and 13. Chapter 14 is concerned with the differential diagnosis and evaluation of these ataxic and paraplegic disorders at various ages. The book concludes with a discussion of genetic counseling. . . . [Full Text PDF of this Article]

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