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Arthur H. Ginsberg, MDCM

Arch Neurol. 1985;42(10):1020-1021.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Myelofibrosis is a progressive and fatal disease of the bone marrow characterized by anemia, weight loss, fatigue, hypersplenism, and death. A patient is described who presented with transient aphasia, papilledema, and two discrete enhancing left-hemisphere lesions noted on computed tomographic (CT) scan. The CT scanassisted needle biopsy revealed pathologic findings consistent with extramedullary hematopoiesis. Steroid and radiation therapy were used successfully to treat this patient. Neurologists should suspect extramedullary hematopoiesis as the cause of symptoms in patients with a history of myelofibrosis who presented with cerebral mass lesions.

Myelofibrosis is a progressive and fatal disorder of the bone marrow that is poorly understood. Central nervous system involvement is rare, however, solid tumors constituted by extramedullary hematopoiesis have been described in cranial and spinal locations.¹ In our patient two discrete tumors were found to originate from the inner table of the skull. One of the lesions produced transient neurologic symptoms . . . [Full Text PDF of this Article]

Author Affiliations
From the Division of Neurology, University of Washington School of Medicine and the Northwest Hospital, Seattle.

Footnotes
Accepted for publication July 14, 1984.

Reprint requests to 1570 N 115th St, Suite 2, Seattle, WA 98133 (Dr Ginsberg).

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