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Sven Ekholm; Harry Fischer, MD

Arch Neurol. 1985;42(1):24-25.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In North America, prior to the introduction of metrizamide (Amipaque), which is a water-soluble, nonionic contrast medium, radiologic evaluation of the subarachnoid space was largely limited to the oily contrast medium iophendylate (Pantopaque).

See also p 39.

The conventional ionic contrast media used for intravascular examinations are, in contrast with iophendylate, of low viscosity and high solubility in water, which allow better visualization of details. Moreover, since they are water soluble they are, in contrast with iophendylate, drained through the arachnoid granulations to the blood and thus are excreted by the kidney. These contrast media, however, are very toxic to neural tissue, partly as a result of their hyperosmolality but also because their ionic structure interferes with the delicate balance between extracellular and intracellular ions that are necessary for normal neuronal function.

The nonionic, low osmolar contrast medium metrizamide seemed at first to fulfill most of the desired criteria for a safe, subarachnoid water-soluble . . . [Full Text PDF of this Article]

Author Affiliations
Rochester, NY

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