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Ivan MacG. Donaldson, MD
213 William Goodenough House Meckleburgh Square London, England WCiN 2AB

Arch Neurol. 1984;41(9):916.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

—The precise role of neuroleptics in the development of permanent neurologic damage due to lithium carbonate has been debated since Cohen and Cohen¹ first reported the association. This is elaborated in detail in our article² along with a possible mechanism for increased toxicity when these agents are combined. It would be wrong, however, to overemphasize this as neuroleptics and lithium carbonate are often prescribed together and may thus be expected to be associated in cases of this type. As we have outlined, other factors may also be important.

Some of the patients who sustained permanent neurologic damage were prescribed doses that were inappropriately large. Others, however, were maintained on conventional doses for long periods and only manifested signs of toxicity when an event occurred to destabilize the situation (eg, infection, dehydration, deterioration in renal function, or the addition of new drugs). Whether one regards the patients as having . . . [Full Text PDF of this Article]

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