This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Sepp Seyfert, MD
Freie Universität Berlin Universitätsklinikum Steglitz Neurochirurg/Neurolog Klinik u Polikinik Abteilung für Neurologie Hindenburgdamm 30 D 1000 Berlin 45, West Germany

Arch Neurol. 1984;41(2):134.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor

—The conclusion of Terrence et al¹ that baclofen in usual therapeutic doses does not seem to be epileptogenic may be based on chance observations. The epilepsy of their six controlled patients usually had a good spontaneous prognosis and was not suitable for pharmacologic treatment. One of these six patients showed a major change in seizure frequency concurrent with baclofen administration, yet previous monthly variation of seizure frequency was not described, making interpretation difficult. Furthermore, serum concentrations of the drugs were not available.

The authors' data argued neither against an epileptogenic nor for an anticonvulsant action of baclofen. It may be remembered, however, that several presumably or definitely seizure-free patients were described who had epileptic phenomena while receiving baclofen. One patient had a generalized tonic-clonic seizure,² and two had myoclonia in the recovery phase after baclofen overdose induced a coma.^3,4 An epileptic stupor with continuous . . . [Full Text PDF of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?