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Their Role in Vasodilatation, Inflammation, and Pain

LORING F. CHAPMAN, Ph.D.; ARMANDO O. RAMOS, M.D.; HELEN GOODELL, B.S.; HAROLD G. WOLFF, M.D.

Arch Neurol. 1961;4(6):617-650.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

Shortly after human skin is injured the area for several centimeters surrounding the site of injury gradually becomes reddened. This flare is a component of the inflammatory response, represents neurogenic vasodilatation,^1-3 and probably is mediated through the release of one or more Vasodilator substances.^4-6 The threshold for pain in the flare zone is lowered.⁷

These phenomena have been the topic of a series of investigations in this laboratory^7-11; in this report an attempt is made to define more carefully (a) the nervous pathways implicated and (b) the nature of the mediator substance.

Antidromic Vasodilatation after Stimulation of the Distal Portion of Transected Dorsal Roots.—In 1874 Goltz¹² demonstrated that the sciatic nerve contains fibers that induce vasodilatation when stimulated. Shortly thereafter, Stricker¹³ concluded that in opposition to the Bell-Magendie law, certain vasodilator fibers apparently leave the spinal cord through the dorsal roots, since . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Study Program in Human Health and the Ecology of Man and the Department of Medicine (Neurology), New York Hospital, Cornell Medical Center, New York. Supported by grants from the National Institute of Neurological Diseases and Blindness, U.S. Public Health Service, and by grants from the Society for the Investigation of Human Ecology.

Visiting Fellow from the Department of Pharmacology, Faculty of Medicine, University of Sao Paulo, Brazil (Dr. Ramos).

Footnotes
Received for publication Dec. 1, 1960.

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