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SIDNEY GOLDRING, M.D.; MICHAEL J. JERVA, M.D.; THOMAS G. HOLMES, M.D.; JAMES L. O'LEARY, M.D.; JOHN R. SHIELDS, M.D.

Arch Neurol. 1961;4(6):590-598.

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The direct cortical response (DCR) is the potential recorded from a cortical locus in response to a surface stimulus applied 2 mm. or less away. It is presumed to arise in the superficial dendritic plexus. The human response has been examined previously by Purpura et al.¹ and by us.^2,3 In our work d.c. recording was used, permitting study of the late components which follow the 20 msec. primary negative potential^* and of the negative potential shift which develops during repetitive stimulation. In our earlier study² all recordings were made during general anesthesia of varying depth. Since then we have examined the details of DCR of rabbit, cat, and monkey with the view of determining the factors which affect the recording of each of the response components.^4-6 In addition, changes in both early and late components due to anesthestic⁵ and convulsive agents^7,8 have been observed, . . . [Full Text PDF of this Article]

Author Affiliations
ST. LOUIS

From the Divisions of Neurosurgery and Anesthesiology, and the Beaumont-May Institute of Neurology, Washington University School of Medicine.

Footnotes
Received for publication Dec. 30, 1960.

Aided by grants from the U.S. Public Health Service (B-1517), and the Allen P. and Josephine B. Green Foundation.

We have discontinued use of the term spike as identifying the primary negative potential of DCR. The neurophysiologist uses that word for conducted all-or-none potentials and epileptologists for unique synchronized discharges which appear in the abnormal electroencephalogram. The first meaning is a far too restricted one for the present purpose, and the second one a much too general application. Present evidence suggests that the primary negative potential of DCR belongs to the class of graded responses of postsynaptic membrane.

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