 |
|
The Blood-Cerebrospinal Fluid Barrier in Man
DAVID P. RALL, M.D., Ph.D.;
EDWARD MOORE, M.D.;
NATHAN TAYLOR, M.D.;
C. GORDON ZUBROD, M.D.
Arch Neurol. 1961;4(3):318-322.
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
|
|
|
The concept of a barrier between blood and cerebrospinal fluid (CSF) has its origins in the many observations concerning the relative exclusion of certain drugs from the fluids of the central nervous system. A standardized technique was developed for a study of the quantitative aspects of transfer of drugs or metabolites across the blood-cerebrospinal fluid barrier in the dog.1 These drug distribution studies indicated that the plasma-CSF barrier is less of a special barrier than had been realized, and that, as far as the behavior of certain organic compounds, it would appear to have properties similar to other biological membranes. As with other membranes, the primarily lipoid nature of this barrier has been noted.1-3 Drugs which enter CSF rapidly and extensively are in general lipoid soluble and undissociated at body pH. Those drugs excluded from CSF are lipoid insoluble and dissociated at body pH since ionized moieties do
. . . [Full Text PDF of this Article]
Author Affiliations
BETHESDA, Md.
Footnotes
Received for publication Nov. 18, 1960.
National Cancer Institute, National Institutes of Health.
Present address of Dr. Moore: Lemuel Shattuck Hospital, Boston.
Present address of Dr. Taylor: Massachusetts General Hospital, Boston.
A portion of this work was presented at the 51st Annual Meeting of the American Society for Clinical Investigation, Atlantic City, May 4, 1959, and an abstract appeared in J. Clin. Invest. 38:1032(June) 1959.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati
What's this?
|
