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The Mode of Action of UML-491 and Its Relevance to the Nature of Vascular Headache of the Migraine Type

DONALD J. DALESSIO; WALTER A. CAMP; HAROLD G. WOLFF

Arch Neurol. 1961;4(3):235-240.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

UML-491,^* 1-methyl-D-lysergic acid butanolamide bimaleate, a derivative of lysergic acid, is being extensively investigated as regards its apparent although limited effectiveness in prevention of vascular headache.^1,2,3 It is known to have an antiserotonin and an antiedema action in laboratory animals.^4,5,6 It is also known not to have a direct or immediate vasoconstrictor action.^8,9 To establish whether or not such antiedema effects of this agent are specific for serotonin, and whether the agent also possesses a nonspecific anti-inflammatory effect in man, a series of observations using manganese butyrate as a noxious agent to induce sterile inflammation were undertaken. Furthermore, observations concerning its central action and its indirect effect on peripheral vascular structures were noted.

Anti Inflammatory Action of UML-491 in Man

The method of Lovell, Goodman, Hudson, Armitage, and Pickering⁷ was applied in order to define whether or not UML-491 has an anti-inflammatory action in human subjects . . . [Full Text PDF of this Article]

Author Affiliations
HELEN GOODELL; NEW YORK

From the New York Hospital and the Department of Medicine (Neurology), Cornell University Medical College.

Footnotes
Received for publication Dec. 1, 1960.

Supported in part by the National Instituteof Health, Bethesda, Md., and in part by the Society for the Investigation of Human Ecology.

The UML-491 was supplied by courtesy of Sandoz Pharmaceuticals, Division of Sandoz, Inc. Hanover, N. J.

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