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Reversible Block of Nerve Conduction by UltrasoundUltrasonic Blocking of Nerve Fibers
ROBERT R. YOUNG, S.B.;
ELWOOD HENNEMAN, M.D.
Arch Neurol. 1961;4(1):83-89.
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Introduction
In recent years ultrasound has found a number of important applications to biological problems. In particular, its destructive effects on the nervous system promise to be of experimental as well as practical value.1-4 In appropriate dosage it may enhance or depress the functional activity of the central nervous system.5,6 Little is known about these functional effects, which do not necessarily involve the production of detectable lesions. This study on peripheral nerve was undertaken to investigate the effects of focused ultrasound on axonal conduction in a mixed nerve, and to shed light on the nature of the central effects.
Methods
The sciatic nerves of large green frogs were used. The branches in the thigh were cut and the main trunk with its tibial and peroneal extensions, measuring about 7 cm. in length, was removed. Distally the tibial and peroneal branches were tied together. The nerve was mounted in
. . . [Full Text PDF of this Article]
Author Affiliations
BOSTON
Departments of Surgery (Neurosurgery) and Physiology Harvard Medical School.
Footnotes
Received for publication Sept. 2, 1960.
This investigation was supported by a Research Grant (DA 49-007-MD 5L3), Department of the Army, Office of the Surgeon General, to the Medical Acoustics Research Laboratory, Department of Neurosurgery, Massachusetts General Hospital, and by Research Grants (B-970 and B-816) from the National Institutes of Health.
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