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Behavioral Effects of Chemical and Electrical Excitation

JANICE R. STEVENS, M.D.; CHUL KIM, M.D.; PAUL D. MacLEAN, M.D.

Arch Neurol. 1961;4(1):47-54.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Studies employing electrical stimulation in chronically prepared, freely moving animals have given disappointingly little information about the functions of the caudate nucleus. In those instances in which positive motor responses have been reported,^1,2,7 there is still the problem of refuting or confirming Kinnier Wilson's arguments that the effects are owing to excitation of fibers of passage.¹⁹

In investigations of the limbic system, we have employed local chemical stimulation of the brain as an adjunct to electrical stimulation.¹³ We have favored the use of acetylcholine or related drugs because acetylcholine is a naturally occurring substance in the brain and may function in the central nervous system as a neural transmitter. The use of cholinergic stimulation for exploration of the functions of the caudate seemed particularly appropriate for several reasons. 1. Such stimulation ostensibly does not excite nerve fibers and would therefore not activate fibers of passage. 2. Similarly, . . . [Full Text PDF of this Article]

Author Affiliations
PORTLAND, ORE.; SEOUL, KOREA; BETHESDA, MD.

Footnotes
Accepted for publication Sept. 16, 1960.

This work was conducted in the Laboratory of Physiology, Yale University School of Medicine, during the years 1953-1956, and was supported by grants from Foundations' Fund for Research in Psychiatry and the National Institute of Neurological Diseases and Blindness of the National Institutes of Health, U.S. Public Health Service.

Assistant Professor of Neurology, University of Oregon Medical School (Dr. Stevens). Professor of Physiology, College of Medicine, Seoul National University; American-Korean Foundation Fellow at time of collaboration in present study (1954-1956) (Dr. Kim). Chief of Section on Limbic Integration and Behavior, Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, Md. (Dr. MacLean).

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