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Some Experimental Observations

ROBERT G. PETERSDORF, M.D.; DONALD H. HARTER, M.D.

Arch Neurol. 1961;4(1):21-30.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Two years after the first description of lumbar puncture by Quincke,¹ Lichtheim noted the sugar content of the cerebrospinal fluid (CSF) to be decreased in bacterial meningitis.² This observation was confirmed by other early investigators³ and, along with the demonstration of micro-organisms by smear or culture, has been recognized as the sine qua non of purulent meningitis for over 50 years. Diminution in CSF sugar to a slighter degree has been described in meningeal infections due to tubercle bacilli, yeasts, and spirochetes,⁴ sarcoidosis of the nervous system,⁵ diffuse leptomeningeal carcinomatosis^6,7 and subarachnoid hemorrhage.⁸

Despite the unquestioned validity of these empiric observations, and the recognized importance of hypoglycorrhachia in differential diagnosis, the mechanism governing the disappearance of sugar from the CSF in any or all of these disease entities remains obscure. Cells, micro-organisms, alterations in meningeal permeability, and accelerated utilization of glucose by . . . [Full Text PDF of this Article]

Author Affiliations
SEATTLE; NEW YORK

From the Departments of Medicine, University of Washington School of Medicine (Dr. Petersdorf) and the Neurological Institute of the Columbia-Presbyterian Medical Center (Dr. Harter).

Footnotes
Accepted for publication Oct. 3, 1960.

Presented in part at the National Meeting of the American Society for Clinical Investigation, Atlantic City, N.J., May 2, 1960.

Supported by Research Grant E3456 of the U.S. Public Health Service and in part by grants from Parke, Davis & Company and The Upjohn Company.

Associate Professor of Medicine, University of Washington School of Medicine; Physician-in-Chief, King County Hospital (Dr. Petersdorf). Chief Resident, Neurological Institute, Columbia-Presbyterian Medical Center (Dr. Harter).

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