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Matti Iivanainen, MD, PhD
Department of Neurology University of Helsinki Helsinki, Finland

Pauli O. Leinikki, MD, PhD
Department of Virology University of Tampere Tampere, Finland

Eero I. Taskinen, MD
University of Helsinki

Isabelle C. Shekarchi, PhD; David L. Madden, DVM, PhD; John L. Sever, MD, PhD
Infectious Diseases Branch Bldg 36, Room 5D-06 National Institutes of Health Bethesda, MD 20205

Arch Neurol. 1982;39(5):321.

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In Reply.—

We appreciate Dr Keshgegian's comments. Following the publication of our report on immunologic abnormalities in the CSF of patients with progressive myoclonus epilepsy, we developed a micromethod for detection of oligoclonal IgG in unconcentrated CSF by polyacrylamide gel electrophoresis.¹ We tested for oligoclonal IgG bands in the same samples (a small amount of CSF was available from each of the 16 patients with progressive myoclonus epilepsy) using our micromethod. A positive finding was detected in 12 of 16 patients. The indirect immunofixation technique, including surface fixation with specific antiserum² and peroxidase-tagged antiglobulin with diaminobenzidine,³ demonstrated that these bands were immunoglobulins of the -G class. . . . [Full Text PDF of this Article]

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