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Frank F. Cook, MD; R. Glenn Davis, MD; Louis S. Russo, Jr, MD

Arch Neurol. 1981;38(7):465-466.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Internuclear ophthalmoplegia (INO) is a sign of dysfunction in the medial longitudinal fasciculus (MLF) and is considered a reliable sign of primary intra-axial pathologic changes in the midbrain and/or pons.¹ It has been described, however, with extramedullary lesions above² and below^3,4 the tentorium. Plum and Posner⁵ suggested that INO is uncommon in coma of metabolic origin and considered its presence a useful differential sign. We report two cases in which unilateral INO was associated with phenothiazine intoxication.

REPORT OF CASES

CASE 1.—A 34-year-old man was found unresponsive at home. An empty bottle that had contained perphenazine and amitriptyline hydrochloride was at his bedside. On admission to the hospital, he was unresponsive to verbal stimuli; his blood pressure (BP) was 100/70 mm Hg, pulse rate was 120 beats per minute and regular, respirations were shallow at 30/min, and temperature was 40.1 °C. He was intubated and given . . . [Full Text PDF of this Article]

Author Affiliations
From the Departments of Neurology (Drs Cook and Russo) and Medicine (Dr Davis), University Hospital of Jacksonville (Fla).

Footnotes
Accepted for publication Nov 20, 1980.

Reprint requests to Department of Neurology, University Hospital of Jacksonville, 655 W Eighth St, Jacksonville, FL 32209 (Dr Russo).

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