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Russell C. Klein, MD; Richard M. Paddison, MD

Arch Neurol. 1981;38(6):392-393.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Carmustine (bis-chloronitrosourea; BCNU), an important agent in the management of astrocytomas and other selected tumors, occasionally causes pulmonary fibrosis.¹ Although steroids have been used to treat carmustine-induced fibrosis, generally without much success, little attention has been paid to the phenomenon of fibrosis developing during concomitant administration of carmustine and corticosteroids. We report such a case and review the available literature on this phenomenon and on the related problem of treating carmustine-induced fibrosis with corticosteroids.

REPORT OF A CASE

A 31-year-old woman was first seen in August 1978 because of a transient bout of incoherent speech. A computed tomography (CT) scan was interpreted as showing an intracerebral hemorrhage, and it was elected only to observe her because she was asymptomatic. In January 1979 the finding on CT scan was still abnormal, and an angiogram suggested a tumor in the left frontal region. Therapy with dexamethasone (8 mg/day) was begun . . . [Full Text PDF of this Article]

Author Affiliations
From the Departments of Medicine (Dr Klein) and Neurology (Dr Paddison), Louisiana State University Medical Center, New Orleans.

Footnotes
Accepted for publication Oct 10, 1980.

Reprint requests to Department of Medicine, Louisiana State University Medical Center, 1542 Tulane Ave, New Orleans, LA 70112 (Dr Klein).

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