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Edward J. Fine, MD
Department of Neurology Rutgers Medical School Piscataway, NJ 02254

Mark Hallett, MD
Section of Neurology Brigham and Women's Hospital Boston, MA 02115

Arch Neurol. 1981;38(2):136.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

Troncoso et al and Rees (ARCHIVES 1979;36:168-169 and 1980;37:397) have reported prolonged latencies of the major positive component (P₂) of the visual evoked response in patients who have subacute combined degeneration resulting from pernicious anemia. Our experience with more complete neurophysiologic testing reveals a distinct pattern suggestive of subacute combined degeneration, which correlates well with the clinical features and the known pathologic finding.¹ The visual evoked response is not the most sensitive parameter. One of the three patients described and one additional patient seen since that time have shown normal visual evoked responses. The most sensitive parameter, which has been abnormal in all cases, is the somatosensory evoked response. A full battery of studies showing an axonal degeneration peripheral neuropathy, normal brainstem auditory evoked responses, mildly abnormal visual evoked responses, and clearly abnormal somatosensory evoked responses paint a picture that is compatible with the diagnosis . . . [Full Text PDF of this Article]

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