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Preliminary Report

Antonio Culebras, MD; Jorge Alió, MD; José-Luís Herrera, MD; M. Isabel Pérez López-Fraile, MD

Arch Neurol. 1981;38(2):133-134.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The availability for human experimentation of an inhibitor of the enzyme aldose reductase (alrestatin) affords the opportunity to test the hypothesis that sorbitol intervenes in the development of diabetic peripheral neuropathy.^1.2 Furthermore, it provides a potential pharmacologic approach to the prevention of peripheral neuropathy and other complications in diabetes mellitus. In this study, we report the effects of alrestatin on ten patients with diabetic peripheral neuropathy.

METHODS

Ten patients entered the study after their informed consent was obtained. Selected patients were of both sexes, between the ages of 43 and 67 years, and had had diabetes for a mean duration of 14.4 years. On admission to the hospital, they were instructed to continue taking their usual fixed-calorie diet, insulin doses, and oral antidiabetic agents.

Physical examinations and laboratory tests were performed before the study was begun and immediately on its completion. The following battery of laboratory tests was performed: ECG . . . [Full Text PDF of this Article]

Author Affiliations
From the Department of Neurology, Upstate Medical Center and Veterans Administration Medical Center, Syracuse, NY (Dr Culebras); and the Fundación Jiménez Díaz, Madrid (Drs Alió, Herrera, and López-Fraile).

Footnotes
Accepted for publication May 26, 1980.

Read in part before the Fourth International Congress on Neuromuscular Diseases, Montreal, Sept 18, 1978.

Reprint requests to Neurology Service (127), Veterans Administration Medical Center, Irving Avenue and University Place, Syracuse, NY 13210 (Dr Culebras).

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