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Dennis J. Selkoe, MD; Kenneth S. Kosik, MD
Mailman Research Center McLean Hospital Belmont, MA 02178

Arch Neurol. 1981;38(12):785.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

We read with interest the article by Cook et al (ARCHIVES 1981;38:300-301) describing the occurrence of Alzheimer's disease (AD) in elderly twin sisters who appeared to be identical. In 1979, Sharman et al¹ first reported the occurrence of histologically confirmed AD in apparently identical 38-year-old male twins whose mother had died of a progressive dementia associated with brain atrophy at age 42 years. In contrast to the cases reported by Cook et al, the twins reported by Sharman and colleagues experienced the onset of dementia within six months of each other at age 34 years, which progressed in identical fashion, and killed them within three months of each other. Frozen brain tissue from one of these twins was further examined by one of us (D.J.S.) biochemically and the results have been reported.^2.3

Most reported cases of familial AD conform to an autosomal dominant pattern with . . . [Full Text PDF of this Article]

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