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False-Positive CSF Cryptococcal Antigen Tests
Stephen J. Kornfeld, MD
Tufts New England Medical Center Boston, MA 02111
Michael Worthington, MD
St Elizabeth's Hospital Brighton, MA 02135
Arch Neurol. 1980;37(9):603.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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To the Editor.—
The diagnosis of cryptococcal meningitis can be an elusive one. Because of the lack of sensitivity of fungal cultures and India-ink examinations, the latex agglutination test for cryptococcal antigen has been widely used to diagnose cryptococcal meningitis. Providing the proper controls are used, the latex agglutination test is regarded as an extremely sensitive and specific diagnostic tool. A commercially available kit (Crypto-LA Kit, IBL Laboratories Inc, Rockville, Md) is currently used by many hospitals, including our own, to perform this test. We have recently seen a patient who had what we believe to be a consistently false-positive cryptococcal antigen test result from the latex test kit.
Report of a Case.—
A 54-year-old man with a two-year history of poorly differentiated lymphocytic lymphoma was admitted to St Elizabeth's Hospital, Brighton, Mass, complaining of frontal headache, fevers, chills, weakness, and intermittent blurring of vision of
. . . [Full Text PDF of this Article]
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