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Giulio Rosati, MD; Isidoro Aiello, MD; Rosaria Tola, MD; Enrico Granieri, MD
Clinica Neurologica dell'Università di Ferrara, Corso Giovecca, 203 44100 Ferrara, Italy

Edmondo Govoni, MD
Istituto di Microscopia Elettronica Clinica dell'Università di Bologna 40100 Bologna, Italy

Arch Neurol. 1980;37(8):530-531.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

The etiopathogenesis of motor neuron disease (MND) is at present unknown. It is likely that various factors play a role in its pathogenesis,^1.2 and certainly anterior horn cell degeneration can occur in a number of other diseases.^3-6 In the patient described here (a more detailed description will be published elsewhere), MND developed during the course of severe thyrotoxicosis, and was diagnosed on the basis of clinical, electrophysiological, and morphological findings.

Report of a Case.—

In a woman who was known to have Graves' disease, a bulbar form of amyotrophic lateral sclerosis (ALS) developed over a six-year follow-up period. The earliest neuromuscular manifestations appeared in 1973 (age 59 years) when, during an episode of severe hypermetabolism, she first noted hoarseness of the voice and difficulty in swallowing. At this time, a neurological examination showed slight weakness of the lower facial muscles, slight dysphagia for liquids, and . . . [Full Text PDF of this Article]

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