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Predominance of Oligoclonal IgG Type in CSF in Aseptic Meningitis-Reply

Aril Fryden, MD
Department of Infectious Diseases

Hans Link, MD
Department of Neurology University Hospital S-581 85 Linköping, Sweden

Arch Neurol. 1980;37(8):530.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In Reply.—

Dr Bollengier's statements are incorrect. The IgG predominance in the CSF from patients with aseptic meningitis was described in 1971¹; seven of 39 patients with a variety of infectious disorders of the nervous system presented in that report (Table 9) had a k / ratio in CSF of 0.5 or less, whereas none of these patients had an abnormally high ratio (>1.7), in contrast to the situation in multiple sclerosis (MS), where 33 of 64 patients had ratios higher than 1.7. The occurrence of free light chains in the CSF from inter alia patients with MS was described already in 1967.²

The report by Dr Bollengier and his group from 1975 was not included among our references because it dealt with MS and subacute sclerosing panencephalitis, whereas the purpose of our article was to introduce immunofixation after agarose gel electrophoresis for the characterization of oligoclonal immunoglobulins with . . . [Full Text PDF of this Article]

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