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Pathokinetic Mechanisms and Molecular Messengers (A Dramatic View)

W. King Engel, MD

Arch Neurol. 1979;36(6):329-339.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To stimulate creative thinking about, and further modeling of, pathokinetic mechanisms, two devices are used herein: personification, from the point of view of the muscle fiber, and juxtaposition of known or probable mechanisms with proposed possible mechanisms. Brutal terms dramatize the death of muscle fibers. "Assassinations" are imposed on the muscle fiber through mechanisms exogenous to the fiber; "suicides" are brought on by endogenous defects of the muscle fiber.

MECHANISMS AND EXAMPLES (CATEGORIZATION ARBITRARY)

Assassination

Assassination, Direct, Simple.—Exogenous poisons, viruses, and protozoa of various sorts can affect muscle cells. They vary regarding specificity for skeletal muscle cells vs other cells. Poisons include bupivacaine,¹ iodoacetate,² 20,25-diazacholesterol,^3-6 2,4-dichlorophenoxyacetic acid,^4,7-11 chlofibrate,¹² perhexiline maleate,¹³ vincristine,¹⁴ and dinitrophenol.^15-16 Myotrophic viruses include coxsackie virus, Theiler's mouse encephalomyelitis and Jungblut's SK virus,¹⁷ avian leukosis sarcoma virus (for avian muscle),^15,18 and mouse C-particle-producing RNA tumor virus . . . [Full Text PDF of this Article]

Author Affiliations
From the National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Md.

Footnotes
Accepted for publication Sept 15, 1978.

Reprint requests to Medical Neurology Branch, National Institute of Neurological and Communicative Disorders and Stroke, Bldg 10, Room 10D20, Bethesda, MD 20014 (Dr Engel).

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