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Meningioma With Creutzfeldt-Jakob Disease
S.M.S. Hayreh, MD;
D.E. McDonnell, MD;
C.A. Aschenbrener, MD
Dept of Neurol Univ of Iowa Hospitals Iowa City, IA 52242
Arch Neurol. 1979;36(3):179-180.
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To the Editor.—
We describe a patient with coincident Creutzfeldt-Jakob disease (CJD) and frontal meningioma in whom the presence of a mass lesion was thought to account for the patient's symptoms and delayed the diagnosis of CJD.
Report of a Case.—
A 78-year-old woman had a rapid onset of bifrontal headaches, with progressive dementia and ataxic gait without incontinence. Examination showed inappropriate behavior, shuffling gait, no papilledema, and mild left-sided weakness without Babinski's signs. Skull roentgenograms disclosed a 4 x 4 x 4-cm mineralized spherical lesion in the right frontal region, which on angiography was seen as
Fig 1.—Right carotid angiogram showing right-sided rounded calcified avascular mass, with shift of anterior cerebral artery to left side of midline.
Fig 2.—Microphotograph of cerebral cortex showing spongiform changes and neuronal degeneration (hematoxylin-eosin stain, x250). an avascular mass shifting the anterior cerebral artery to the left (Fig 1). A meningioma was removed. Postoperatively
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