
Intraocular and Intraventricular Pressures After Glycerol Ingestion
K. K. Kugler, MD
1705 E 19th St Suite 210 Tulsa, OK 74104
A. R. Dick, MD
Section of Neurosurgery Dept of Neurology
S. R. Nelson, MD
Dept of Pharmacology Univ of Kansas Med Center Kansas City, KS 66103
Arch Neurol. 1977;34(7):451.
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To the Editor.—
A noninvasive indicator of intracranial pressure would be especially useful to determine when an administered hyperosmotic diuretic is no longer effective. Lehman et al1 reported a correlation between increased intracranial pressure and intraocular pressure in monkeys. We made a series of intraventricular and intraocular pressure measurements three times in two patients with aqueductal obstruction treated with glycerol. One series of measurements from a patient with a metastatic cerebellar tumor is given in the Figure.
Intraocular pressure decreased 15 minutes after glycerol ingestion; intraventricular pressure decreased 30 minutes after ingestion. Both pressures remained low for about 90 minutes, then the intraocular pressure increased and plateaued while the intraventricular pressure was still increasing.
The correlation between changing intraventricular and intraocular pressures recorded here and observed in two additional series of measurements suggests that ocular tonometry may be useful as a monitor of change in intracranial pressure. Due to the
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