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J. E. Desmedt, MD; S. Borenstein, MD
Brain Research Unit of the Univ of Brussels, 115 Blvd de Waterloo B-1000 Brussels, Belgium

Arch Neurol. 1977;34(4):259.

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In Reply.—

The comments by Dr Coërs relate to questions that we of course considered in detail when we first found the significantly increased incidence of linked potentials associated with the myopathic motor units in muscles with Duchenne muscular dystrophy (DMD)¹ (Arch Neurol 33:642, 1976). We concur in the opinion that no motor axon loss takes place in DMD, and furthermore that an unemployed axonal branch having lost its muscle fiber through the dystrophic disintegration process might very well take up a new job by innervating a newly formed muscle fiber resulting from either segmental necrosis or myotube regeneration, as we proposed. The issue whether such innervation of the newly formed muscle fibers is achieved by axonal branches that either belonged to the original motor axon arborization or represent new collateral sprouts thereof is of course pertinent, but appears indeed of secondary interest with respect to the major problem raised by . . . [Full Text PDF of this Article]

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