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W. J. Gardner, MD
Cleveland Clinic 9500 Euclid Ave Cleveland, OH 44106

Arch Neurol. 1977;34(3):200.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

In 1914, Lewis Weed¹ stated:

Assuming osmosis to be the power of concentrated fluids to attract water or fluid from less concentrated solutions, it is not difficult to explain the normal physiologic process of absorption of cerebrospinal fluid on this basis; for the venous blood certainly possesses a greater concentration in colloids and crystalloids than the cerebrospinal fluid.

But some investigators still search for anatomic valves in the arachnoid villi. In 1917, Weed² described the development of the cerebrospinal fluid spaces in living pig embryos. This contribution established for all time that these spaces develop in embryonic life in response to hydrodynamic stresses occurring within the neural tube after it has closed. However, recent authors have denied that such hydrodynamic stresses constitute the basis for the development of the Dandy-Walker and Arnold-Chiari malformations.

In 1925, Cushing³ described the cerebrospinal fluid as the brain's "third . . . [Full Text PDF of this Article]

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