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R. C. Collins, MD
Dept of Neurology Washington Univ School of Med St Louis, MO 63110

Arch Neurol. 1977;34(1):57-58.

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In Reply.—

Hypercarbia decreases 2-deoxyglucose (2-DG) uptake in brain.¹ This reflects a true decrease in glucose utilization during hypercarbia, as there is both a decreased need for glucose since metabolic rate is depressed,² and there is an inhibition of glycolyses mediated by the effect of pH on phosphofructokinase.³ Uptake of 2-DG is mediated by the glucose carrier and is dependent on concentration but independent of blood flow. As used in our study, it would be independent of a breakdown in the blood brain barrier. The autoradiographic density reflects 2-DG that has been metabolized by hexokinase and trapped as 2-DG-6-phosphate. Forty-five minutes after an intravenous bolus injection, less than 10% would still remain in the precursor pool. The arterial plasma concentration of 2-DG decreases exponentially after a single injection, and even if this were freely diffusable with extracellular spaces it would not add detectably to the autoradiographic picture.

Breakdown of . . . [Full Text PDF of this Article]

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