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R. Myers, MD, PhD; F. W. Gamach, Jr, MD
Laboratory of Perinatal Physiology NINCDS, Natl Institutes of Health Bethesda, MD 20014

Arch Neurol. 1976;33(4):307-308.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In Reply.—

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Factors such as hypoxia and acidosis occurring during the insult and recovery periods... probably account for neuropathological sequelae described by others.

A reading of Brierley and Meldrum's text reveals insufficient control of the conditions of their experiment. Their work could be titled "Brain Damage in Rhesus Monkeys Resulting From Profound Hypotension Combined With Severe Hypovolemia of Variable Duration (From 1 to 54 Minutes), Carried Out at Various Body Temperatures (From 34.1C to 38.6C), of Various Rapidities of Onset (From 2 to 44 Minutes), With the Episodes Sometimes Repeated, and With the Animals Sometimes Breathing Spontaneously, Sometimes Mechanically Ventilated, With Superimposed Alkalosis and Hypocapnea (Mean pH, 7.54 and Mean Pco₂, 24 mm Hg), and With a Prolonged and Variable Rate of Restoration of Blood Pressure Afterwards." Despite variable animal treatment, the authors attribute the two pathologic outcomes (focal necrosis and diffuse . . . [Full Text PDF of this Article]

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